Viagra tablets are the invention by Pfizer, Inc., whose popularity is not only down to their efficiency to produce rock-hard erection among a group of men suffering from a kind of impotence known as erectile dysfunction, but also because they have a seeming knack for reinventing themselves.
A report emanating from a hospital in Tyneside, Newcastle on the 15th of February 2007 told of how Viagra tablets were used to save the life of an infant.
According to the report, Lewis Goodfellow had weighed about 1pound and 8 ounce after been born prematurely at 24 weeks. The oxygen supply to Lewis’s bloodstream was not enough because his lungs had failed.
As a last ditch effort to save young Lewis’s life, the doctors at the Royal Victoria Infirmary, the hospital where Lewis had been born, had decided to administer Viagra, the citrate salt of Sildenafil Citrate, on the baby.
The fact that Viagra could open up tiny blood vessels in the baby’s lungs to allow for oxygen to be absorbed into the bloodstream, apparently, must have informed the doctors’ decision.
After saving young Lewis’s life with the novel effort, Alan Fenton, consultant neonatologist at the hospital, explained their decision thus:
‘The problem with most prematurely born babies that have difficulties with their breathing is that not enough blood is supplied to their lungs to allow for the circulation of oxygen to the other parts of their body, even in cases where oxygen is blown into their lungs to help them. What Viagra does is that it could help in opening up the blood vessels so that oxygen could be captured and be subsequently distributed to the rest of the body.’
Viagra tablets, in line with keeping to their headlines-grabbing tradition, were again in the news on the 14th of February, 2007 when a pilot scheme to trial the sale of the drug over-the-counter was carried out by Boots the chemist.
Under the scheme, three pharmaceutical stores in Manchester, England, would be stocked with Viagra tablets, and the scheme will afford those who want to buy Viagra online with no prescription the opportunity to do so. If successful, the scheme would be carried out on a national scale and Viagra tablets would be made available to all the pharmaceutical stores nationwide.
Of course this does not mean that standard ethical practice would be discarded in dispensing the drug, as customers who want to buy Viagra tablets at these stores, but who do not have prescription, would be asked some salient questions relating to their suitability to buy the diamond-shaped blue pills.
Before a customer can buy a packet of four Viagra tablets, for example, he is expected to give out information on his medical history to the pharmacist, and also present himself for blood pressure, cholesterol and glucose levels, tests.
A positive angle to this novel scheme is that it avails the vast number of people who couldn’t get prescription for the blue pills, but who nevertheless want to buy Viagra tablets a great opportunity to be part of the Viagra revolution.
Out of the estimated 3 million men in Great Britain suffering from erectile dysfunction, according to Boots, only 10 percent of this group receive treatment. The scheme would make more Viagra tablets available to ease the problem of the vast population of the untreated class of people between the ages of 30 and 65 that would be eligible to buy.
Any man who desires a regular supply of Viagra tablets would be made to consult with a doctor at a fairly affordable price of about 35.5 pounds. And once he is certified fit to buy the drug, it would be made available to him at the cost of 21.25 tablets per 4-packets pack.
Filed under Blog, Sildenafil Citrate by 
Viagra as an effective Erectile Dysfunction (ED) treatment
[mage source="flickr"]Viagra as an effective Erectile Dysfunction (ED) treatment[/mage]
Ed Treatments No Longer Limited! Try Out the Options Available
Erectile dysfunction became more popular amongst the common man not because of its nature but because of the treatments that were invented for the disease within the space of the last ten years. Erectile dysfunction was a matter of great concern and worry among the common man because earlier there were no convincing treatments for the disease. But now oral ED pills are doing very well as regards to ED cure.
Though the objective of all the oral ED drugs is the same, their components are slightly different. The first phenomenal ED drug to be invented, as we all know, was Pfizer Viagra. This ED drug inspite of being extremely popular and effective in ED treatment, proved to be of little use to a considerable number of ED patients. Not only ED, this happens in case of patients suffering from other diseases also. There are many people who cannot be administered the most popular drug of a particular disease, as the drug might not suit them. Similarly in case of ED also there are patients who cannot be treated with Viagra. These patients are often collectively termed as the Viagra non responders.
Therefore for these non responders there had to some kind of an equally effective alternative or for that matter alternatives. The medical giants started working on ED medications that could be as effective for those who cannot be treated by Viagra and also for those who can be. As a result today we have three prominent ED pills that are collectively thought to be the best form of ED cure.
These new ED cures are however not devoid of the side effects that their predecessor had. What they did was that they concentrated on developing some kind of an advantage or advantages over their predecessor. Something special and extraordinary that could not be found in Viagra.
The marketing strategy of these competitors bore fruits as today all of them are surviving in the market for ED cure. They have takers and their set of customers. All these drugs have even ventured into the online pharmacies with the hope of getting their product right into the bedroom of the customers, where they are actually meant to be! One thing that is however common with all the ED drugs is their abuse. Almost all the ED drugs are used for purposes that they are not meant to serve.
Well, coming back to the topic of the Viagra competitors, the latest one to join the band wagon was Bayer Levitra. Counted among one of the cheapest ED drugs, Levitra online also has the advantage of being applicable to the patients of hypertension and diabetes. People can order levitra once they are approved the Levitra prescription. Please do not go for online pharmacies which claim to sell cheap levitra, always buy levitra from a well known online store selling the FDA approved levitra pills.
Encore Revive Premium – As seen on TV – Proven Impotence Treatment Covered by Medicare
Filed under Impotence, Prescription Viagra, Sildenafil Citrate by
Does Viagra improve the heart condition?
[mage source="flickr"]Does Viagra improve the heart condition?[/mage]
“me-too†Drugs: Good or Bad?
Introduction
A drug that is structurally very similar to already known drugs, with only minor differences. The term "me-too" carries a negative connotation. However, me-too products may create competition and drive prices down1.
The majority of the new products the industry puts out, are “me-too” drugs, which are almost identical to current treatments but “no better than drugs already on the market to treat the same condition.” Around 75 percent of new drugs approved by the FDA are me-too drugs. They can be less effective than current drugs, but as long as they’re more effective than a placebo, they can get the regulatory green light2.
This isn’t surprising at all, as someone who works in the field, but these so-called “me-too” drugs, which are reportedly better than their forebears, is driving costs. A “me-too” drug is a drug that has its origins in another drug. Probably the most famous example of this is Prilosec (“The Purple Pill”) and Nexium (“Today’s Purple Pill”). Prilosec’s active ingredient is omeprazole. Nexium’s active ingredient is called esomeprazole. The difference is that Nexium is the left-handed version of omeprazole. In chemistry, S stands for sinister, which means the molecular conformation has a left-handed orientation. (D would be right handed.) So this S-omeprazole is one half of the mixture that comprises its predecessor. By specifically picking only the S conformation, the drug is made more potent. This sounds great, but its efficacy is only marginally better than Prilosec-, which has a generic version, and costs about a third less than Nexium. Some other “me-too” drugs are: Claritin (loratidine) and Clarinex (desloratidine), Celexa (citalopram) and Lexapro (escitalopram)3.
What are "Me-Too" drugs?
Ever since the advent of modern chemotherapy, when drugs were discovered and developed through the process of screening thousands of molecules for a variety of disease conditions, using animal models, there has been a growing criticism that too many molecules were developed with similar chemical structure and the same pharmacological profile, with very little to distinguish them from each other in terms of their therapeutic utility. In other words, once the first breakthrough discovery is made of a new pharmacological activity for a new molecule, subsequent years saw the emergence of a host of new molecules or "me-too" drugs from the same chemical class and possessing the same pharmacological profile.
Such follow-up drugs have been termed molecular modifications, molecular roulettes or copycats, the development of which are alleged to be motivated by purely commercial considerations. They are also deemed to involve lower levels of innovation, compared to the original molecule. It is important to analyze in a historical perspective the end results of such efforts in different therapeutic areas of developing new molecular entities, as later generation products, after an initial breakthrough discovery has been made and the technical, medical and commercial merits of developing such drugs.
Development of "Me-Too" drugs
The success rate in the discovery of new chemical entities with fundamentally new chemical and biological profiles of activity are very low. In fact, even chemical entities within the same structural class of an approved drug are becoming rare now, compared to the period of sixties to eighties. In 2001, $ 26 billion was spent on developing new drugs and the U.S. FDA approved only 9 new chemical entities. At the same time, two thirds of the drugs approved from 1989 to 2000 were modified versions of existing drugs or even identical to those, in newer forms and formulations4.
Of the 1,035 drugs approved by FDA during 1989 to 2000, only 361 or 35% contained new active ingredients. Of these, only fewer than half were granted priority review status by the FDA. One impression is that these drugs are slightly altered versions of existing drugs, with little to offer in terms of better activity or tolerance, let alone new pharmacological profiles. The implication is that such drugs are developed, as patents on top-selling original drugs run out and not many truly new medicines are discovered. The indication that many of these drugs do not offer any major advantages over existing drugs is given by FDA's unwillingness to grant priority review for most of them.
On the other hand, conventionally, the Regulatory Agencies, including the FDA, are not obliged to consider better efficacy over existing drugs as a criterion for approval; rather, they require only the establishment of efficacy and safety of the new drug over a placebo.
How good are they?
Notwithstanding such perceptions, historically, many "me-too" drugs have proved to be considerably better than their original counterparts. Examples are a series of generations of beta-blockers, which came up after the original drug Propanalol was discovered by ICI, with most of them having merits in terms of better efficacy, cardio-selectivity and safety. Ranitidine, the first follow-up drug after the introduction of the first H-2 receptor antagonist, Cimetidine, was followed by Famotidine and in each case these "me-too" drugs had notable merits over the original drug.
Apart from the major breakthrough in the development of orally active beta lactam antibiotics of the Penicillin and Cephalosporin class, within the same oral derivatives, there have been considerable improvements brought about by change in the side chains incorporated by condensation of specific agents with 6-APA, 7-ADCA and 7-ACA. A whole new range of broad-spectrum antibiotics of these structural classes could thus be developed. In each of the major classes of antibiotics, classified according to the mechanisms of their action, namely inhibition of cell wall synthesis (Beta Lactams, Vancomycin), inhibition of bacterial protein synthesis (Erythromycin, Tetracycline, Streptomycin), inhibitors of DNA or RNA replication (Quinolones, Rifamycins), inhibition of Folate Coenzyme biosynthesis (Sulfa drugs, Trimethoprim), there have been several "me-too" drugs marketed.
An important recent example to show that 'me-too" drugs need to be developed is the case of the oral hypoglycemic drug Troglitazone, approved as an anti-diabetic drug in 1997. The drug was withdrawn from the market following reports of unacceptable hepato-toxicity. The follow-up "me-too" drugs, Rosiglitazone and Pioglitazone are much less toxic and are today widely used. If these drugs were not developed, the withdrawal of Troglitazone would have left a major therapeutic gap in anti-diabetic therapy.
"Me-Too" drugs: Strategies for New Drug Research for Indian Companies
Breakthrough innovations in pharmaceutical industry, of new drugs, such as the first beta blocker, the first NSAID, the first of each class of Antibiotics, Calcium Channel blockers, ACE inhibitors, Sulfonyl Ureas, Biguanides, Insulin, Glitazones, Glinides, Tricyclic Anti Depressants,major and minor Traquillisers, Selective Serotonin Receptor inhibitors, H-1 and H-2 Receptor antagonists, Proton Pump inhibitors etc are relatively rare and even though a few of the original drugs under these classes are still very much in use, they have been superceded in most cases, by later generation products, many of them "me-too". The newer drugs are discovered both through incremental innovations on the original drugs as well as through new research.
Generally the original discovery leads to feverish activity both within the innovator company as well as in Competitors' laboratories, to develop better products in the same therapeutic category. The essential caveat for commercial success, however, is that the newly discovered molecules should meet the minimum standards of patentability. For example within three years of the discovery of the highly successful Sildinafil Citrate (Viagra), three more new versions for the same indications have been patented and developed5.
Me-too drugs also provide therapeutic advantage6. For the practicing physicians, there's the benefit of established drug MoA with a "me-too" medication, coupled with clinical studies that – hopefully – show patient-centered benefits such as better adverse events profiles, less frequent dosing, less bothersome potential for drug/drug interactions, and so forth. A "me-too" drug is a helluva lot easier to incorporate in practice than a totally novel medication7.
"Me-Too" drugs: The hidden dynamics
The most common criticism of drug development centers on the so-called "me-too" drugs that employ the same biological mechanism as pioneer brands. This involves a lot more than such high-profile targets as the anti-ulcer drug Nexium. We should be thinking about antidepressants, cholesterol-reducing drugs, diabetes treatments, anti-psychotics, and other therapeutic categories that have seen both blockbuster sales and rapid innovation. There is quite a bit of evidence that follow-on drugs do a lot of patients a lot of good. The newer statins, for example, often out-perform the older ones in clinical trials where the endpoints are the number of heart attacks and deaths prevented.
Me-too drugs are also a powerful tool for cutting health care costs. We should be glad that our research industry does not target only brand new biological mechanisms. That would be a very expensive business model indeed. Fortunately, the industry also works on marginal improvements, exploiting opportunities to make drug therapy better and sometimes opening the door to really radical improvements that happen to lie more or less next-door, scientifically speaking. In the meantime, we get price competition as a by-product. Me-too's almost always undercut the prices of the pioneer drugs.
Another part of the me-too story gets almost completely ignored even though it is extraordinary important. For me-too manufacturers, advancing the science is a way to gain a competitive advantage. The classic example is the statin class of cholesterol drugs. Research on one of the follow-on drugs (Pravachol) demonstrated for the first time that using a statin to reduce cholesterol would actually prevent deaths from heart attacks, something that had previously been assumed without proof. Additional trials for several statins, including Lipitor, the formidable challenger to Zocor and Pravachol, have demonstrated that serum cholesterol is far more important than almost anyone thought (for preventing strokes, for example).
There are lots of other stories about the benefits of new research from me-too drugs, but they are part of a larger story: new uses for old drugs. The data showing a slowdown in new drug approvals exclude essential information: discoveries of new uses for old drugs. This kind of discovery has become so common that it amounts to a "new-use" revolution. One of the scientific ironies of the new era of pharmaceutical research is that as drugs become more tightly targeted on biological mechanisms, their uses actually become more diverse. This is because the body typically uses specific mechanisms over and over again, sometimes in what appear to be completely unrelated ways.
Consider the SSRI antidepressants. A recent Science article on the diverse and unexpected applications of drugs that fiddle with serotonin reuptake which is what the SSRIs do concluded that the very term "antidepressant" is misleading because there is no scientific reason to think of this drug as being just for depression. Fighting depression just happened to be the first really useful condition that was explored for this very interesting class of drugs.
Another example is the Cox-2 inhibitors like Celebrex (and Vioxx, which is important in this story and may return to the market partly for this reason). These were invented to relieve arthritis pain. But the Cox-2 enzyme turns out to be important for lots of things including cancer and Alzheimer's. Clinical trials to exploit these leads have been underway for years. Celebrex has already been approved for reducing the risk of colorectal cancer, and Vioxx has also achieved promising results. Of course, the big news recently has been that these drugs may cause heart attacks. But even here, me-too economics is of surpassing importance. The traditional NSAIDS (non-steroidal anti-inflammatory drugs) like Alleve and Advil may have the same heart attack risks. The potential risk has been there for decades, but only the new drugs-the Cox-2s-have been put through large-scale long-term clinical trials because those are the only ones still under patent. This is an example of how me-too drug development adds importantly to the research base. Thanks to the me-too's, we are learning about NSAIDs, heart attacks, cancer and probably much more.
Also dominated by new uses are the new-targeted cancer drugs, which attack such specific biological mechanisms that they avoid killing every fast-growing cell in sight (as traditional chemotherapy tends to do).
The implications are clear. The annual count of new drug approvals will only show a tick when a new cancer drug or a new statin gets its very first approval. But a new use for an old drug can be as valuable as an entirely new drug, or even more valuable when you consider that we know more about the safety profile of old drugs and one drug will sometimes do the work of two (preventing both heart attacks and strokes, for example)8.
Me-too products can sometimes have important advantages on tolerability or dosing. It could help create more competition and lower the price. If you have five me-toos, possibly the sixth is something that is a little better. That is for the plans to decide on behalf of their patients. And even if it has the same mechanism of action, more competition could help drive down the price of the entire class. That’s an important influence, with potentially an improvement in health from greater access.
How bad are they?
Even though the major problem of antibiotic therapy, namely drug resistance cannot be addressed by the development of "me-too" drugs, due to the propensity of the same class to develop cross resistance; in most cases, the new semi-synthetic derivatives had distinct advantages over the earlier ones. Thus, for example, the first generation Cephalosporins are useful for gram-positive infections, while the second-generation drugs cover a broader spectrum including gram-negative organisms. The third generation drugs provide resistance against the beta lactamase enzyme, as well as acting against some of the most intractable infections, such as those caused by Pseudomonas and Klebsiella strains.
Even while the pharmaceutical industry turns out families of me-too drugs for relatively mild conditions in affluent people, it pays almost no attention to serious diseases, such as malaria, affecting impoverished people. It also gives short shrift to less profitable drugs, so there now are shortages of some vaccines and life-saving drugs9.
The big problem with me-too drugs is that they are chemically very similar to other drugs already available, yet they are marketed as if they were important new breakthroughs, with very high prices. Many new, expensive me-too drugs are not necessarily better than older and less expensive drugs. Most of the time they are compared with placebos and not older drug comparisons.
"Me-too" drugs are responsible for 80% of increased spending in recent years, and on average they are four times more expensive than the comparable, older alternatives10. By Patented Medicines Pricing Review Board's (PMPRB) definitions, at the time of their introduction “me-too” drugs were judged to provide moderate, little or no improvement – in terms of effectiveness and safety – compared to older alternatives. However, on average, “me-too” drugs cost about 2.5 times as much per prescription as comparable older drugs. The question is whether the perceived or real differences justify the increased costs. New drugs do have a role in some situations and for some patients. However, it makes sense to use the older equally effective drugs whenever possible11.
Changing FDA rules to discourage me-too drug approvals would make R&D far more expensive, would discourage competition and therefore raise healthcare costs, and would forestall the wave of new research that has revolutionized our scientific understanding of the therapeutic categories where competition has been most intense.
Conclusion
New drugs are not required to improve on old ones, and there’s usually no way to know whether they do. Although the FDA must test drugs before they are marketed, they don’t need to be compared with similar drugs already on the market. The FDA only requires they be reasonably safe and better than nothing-a low standard indeed. This loophole in FDA regulations opens the door for an unlimited number of me-too drugs, which are easier to develop than innovative drugs.
Given everything, it should come as no surprise that these more expensive “me-too” drugs cost the medical industry money. The prevalence of the me-too's really says an awful lot about the lack of innovation within the pharmaceutical industry. If you look at the new drugs marketed over the last six years, 78 percent weren't even new chemical compounds. They were just new combinations or different formulations of old drugs. And 68 percent were classified by the F.D.A. as unlikely to be improvements over drugs already on pharmacy shelves.
At the same time, there are shortages of some important drugs that the pharmaceutical companies aren't much interested in making because they are not as profitable as the me-too's. But the companies don't have to turn out needed drugs, if they are not lucrative. And they don't.
References
1. http://www.medterms.com/script/main/art.asp?articlekey=33748
2. http://www.motherjones.com/news/qa/2004/09/09_401.html
3. http://polyscience.org/2005/09/me-too-drugs
4. http://www.shvoong.com/books/465475-me-too-drugs
5. http://www.pharmabiz.com/article/detnews.asp?SecArch=&articleid=14604§ionid=46
6. http://direct.bl.uk/bld/PlaceOrder.do?UIN=162532605&ETOC=RN&from=searchengine
7. http://www.archivum.info/sci.med/2005-09/msg00257.html
8. http://www.aei.org/publications/filter.all,pubID.27443/pub_detail.asp
9. http://blogs.wsj.com/health/2007/05/17/in-praise-of-me-too-drugs
10. http://www.chepa.org/KnowledgeExchange/LabelleLectureship/tabid/84/Default.aspx
11. http://www.ti.ubc.ca/pages/letter59.html
Viagra amplifies the effects of a heart-protective protein
Filed under High Blood Pressure, Impotence, Sildenafil Citrate by
All You Need to Know About Low Libido
What Causes Low Sex Drive? What Can You Do?
If you're a man in mid life experiencing reduced sexual desire you're not alone. Surveys show as many as 25% of men experience reduced sex drive and low sex drive affects one in three marriages. When low sex drive is mentioned, the spouse with the problem is usually categorized as the wife. However, there are many husbands who aren't interested in sex with their wives. And there is plenty you can do to boost low libido and restore normal desire.
Low Sex Drive More Common Than You Think
Men find it hard to admit to or talk about low sex drive because being sexual is so much part of being a man. But low sex drive is a more common problem than you might think. Declining testosterone levels as a natural consequence of aging, plus stress from work and family demands can add up to sexual burn out. Sexual therapists report increasing numbers of men who experience low libido – and it's often made worse because people find it so difficult to talk about. § Complaints about low desire are the No 1 problem brought to sex therapists.
Low Libido – You Don't Have to Put Up With It
Whether lack of desire originates with husband or wife, the end result is the same. There is a lack of physical contact, which is experienced by the other partner as the ultimate rejection. Many couples think they are the only ones with the problem. They feel as though nothing can be done about it. But low libido is a problem that's actually increased with the stresses of modern life – and sex is such a vital part of our lives no one should accept it's "all over". So if anyone tells you that a declining sex drive is something that you just have to put up with as you get older – they're wrong.
Low Libido – What You Can Do About It If anyone tells you that low libido is something that you just have to put up with as you get older – they're wrong. Thousands of men and women are discovering the benefits of natural sex boosters like tribulus terrestris, horny goat weed, maca, muira puama, and ginseng. Modern science and traditional medicine have joined forces to show how popular natural sex boosters work. Many of the active ingredients in traditional herbs have been investigated to work out just what it is in the herb which gives the good results. Those ingredients, in the form pure measurable active extracts, are now available in dietary supplement capsule which are easy to take and don't cost a lot. However do not expect these natural products to work as quickly as pharmaceuticals, Natural sex boosters work a little slower, and while they may take a few days to work, they often provide additional benefits such as boosting libido and enhancing sensations.
Low Libido – Five Steps to Boost Desire Just Do It – frequent sex helps jump start desire.
§ Tailor activity to hormonal highs: Men's testosterone, a primary hormone responsible for sexual desire, peaks at 7 to 8 in the morning.
§ Don't bury your head in the sand. Ignoring the problem isn't healthy. You need to get help.
§ Talk about what you need. § Don't keep score. Stop the blame game. It's a couple problem that requires change from both of you.
Low Libido Is NOT Impotence Low libido is the same as low sex drive – but not the same thing as impotence or erectile dysfunction. Impotence or ED is wanting to have sex but not being able to carry through on the desire. Low libido is having little desire for sex even if you are capable of achieving erections. Causes of Low Libido in Men The causes ofLow Libido in men are physical and psychological.
Physical Causes of Low Libido
§ Alcoholism – most common § Drug abuse – cocaine and marijuana § Obesity – common
§ Diabetes or other "major" disease
§ Prescribed drugs, particularly Proscar, a tablet used for prostate problems
§ Low testosterone levels
§ Thyroid disease Psychological Causes of Low Libido
§ Depression – most common § Stress and overwork
§ Performance anxiety § Latent gayness § Serious relationship problems What Can You Do About Low Libido in Men
§ Check hormone levels
§ Have a health examination
§ Get testosterone supplementation if necessary § Consider supplements
§ Lose weight
§ Exercise
§ Control stress § Stop smoking
Check Hormone Levels
Men should have testosterone, DHEA and other androgen levels checked whenever there is any noticeable reduction in sex drive.
Have a Health Examination
Low sex drive may be the result of a thyroid condition,diabetes, hypertension, high blood pressure or other major illness. You should also discuss what other medications you are taking, because some anti depressants, tranquilizers and antihypertensive drugs as well as illegal drugs like marijuana and cocaine can reduce sex drive.
Get Testosterone Supplementation if Needed For
Men, lifting testosterone levels can make a big difference in restoring libido and sex drive to normal levels. Testosterone is available in pill or patch form, or can be accessed by taking herbal formulas like proprietary supplement Herbal Ignite, containing Tribulus Terrestris.
Consider Supplements to Help Low Libido
Increasingly herbs which have been used traditionally by ancient peoples for thousands of years are being identified in modern science as useful for sexual enhancement.
Herb Name Herb Information
Avena Sativa Wild oats. Helps with stress, has been used to help nicotine withdrawal, improves sex drive.
Tribulus terrestris Stimulates the body to produce more testosterone rather than introducing a synthetic form.
Damiana This South America shrub has a testosterone-like effect and has long been associated with increasing male potency.
Gingko Biloba Used in the East for thousands of years. Research has shown it improves depression, circulation and blood flow to the brain.
Horny Goat Weed A popular herb for improving sexual function.
Yohimbe A hormone stimulant that increases libido and blood flow to erectile tissue Not available only in some regions because of the side effects which can include anxiety, panic attacks, and hallucinations, elevated blood pressure heart rate and headaches.
Zinc An essential mineral for prostate gland function and the reproductive
health. Do not take more than 100mg a day.
Saw palmetto Excellent herb for prostate health, sexual functioning and desire.
Guarana South American shrub used as a stimulant.
Ginseng Used throughout the Far East as a general tonic to give extra energy and strength. Beneficial for people with diabetes.
Lose Weight to Help Improve Low Libido Easier said than done for sure, but the uncomfortable reality is big bellied men have flagging libido. Men with a 42 inch (106 cm) waist are more than twice as likely to have erectile problems andLow Libidothan those with smaller girths, according to a study of 2000 men aged 51 to 88. According to Larrian Gillespie MD author of The Gladiator Diet "for men, losing as little as ten pounds can have a dramatic effect on sex drive." As the balance of body fat reduces, the more free circulating testosterone there is available to fuel sex drive.
The Gladiator Diet is based on a diet that should be 40% protein, 35% carbohydrates and 25% fats taken in six small meals a day.
§ Forget low carb fad diets. Only a diet that includes protein and carbs produces enough serotonin "the male hormone of bliss" according to Jed Diamond, author of The Irritable Male Syndrome – Managing the 4 Key Causes of Male Depression and Aggression.www.menalive.com
§ Alcohol gives serotonin a temporary bump but then dramatically lowers it, so it pays to go easy on booze.
§ To maximize testosterone, Diamond says, stay away from coffee, licorice and diet sweeteners.
Exercise to help Improve Low Libido Research shows inactive men are more likely to suffer Erectile Dysfunctionthan men who exercise for at least 30 minutes a day.
Five Essential Habits for Stress Control
§ Develop your relaxation skills § Pay attention to physical health
§ Become a time management expert
§ Exercise regularly
§ Prioritize commitments and responsibilities
Check out these stress tests for a range of tests you can take to learn more about your own stress levels and ability to cope. Or try the free stress test at Stress Canada and find out whether you are a Speed Freak, a Loner or a Drifter – three of five stress types identified in research.
Stop Smoking to Help Improve Low Libido
Smoking can lower testosterone and increases the risk of heart disease, stroke, aneurysms, and hypertension because of elevated cholesterol levels. You can also add impotency to that group, as elevated cholesterol clogs the sensitive small blood vessels responsible for trapping blood in the penis during an erection.
Don't Put Up with Low Libido
You don't have to be the one staying up watching TV, waiting for your partner to go to bed first, hoping she'll (or he) will be asleep before you get to bed. You don't have to put up with the guilt of feeling you can't respond and that you can't talk about it either. Many men take years to admit there is a problem and get around to doing something about it. Consult your health practitioner, research possible dietary supplements on the web, or talk to your pharmacist, and take action for a fuller and more enjoyable sex life.
Filed under Blog, Impotence, Sildenafil Citrate by
Is Viagra better than Cialis and Levitra?
[mage source="flickr"]Is Viagra better than Cialis and Levitra?[/mage]
Is Male Enhancement Right to Increase Men Penile Size
Male enhancement works for many men. There are many male enlargement products that are clinically tested and doctor approved. Penis enlargement products increase men penis size from 3 to 5 inches. Some of men do not reach this length but some do. It depends on how often you use it. To protect your sexual life with your partner, men should try penis enhancement products to enlarge their penile sizes. No matter who can use a device of traction, and there is no restriction of kind on what makes with a better man adapted to employ them. Those – are strongly recommended for the men who are interested by results of quality, and which do not have any exit with taking their time. Permanent profits are made slowly above much month, thus if you are laid out with being patient, you are well adapted to this method.
The majority of the men consider if they should have the improvement of penis at a certain point in their lives. And when they look in him, they inevitably find the variety of methods available for the goal. The quantity of information available can make your principal rotation! You are a good candidate for the surgery of improvement of penis if you are in relatively good physical health, and have the moment for the process of re-establishment. Since the surgery is relatively invahissante, to have a strong constitution makes you a better candidate, because you will be far less likely from the secondary infection. The smokers tend to have a rate much slower of cure according to how long they had smoked.
Single of the attention: if you have medical conditions for which you take the drug, consult your doctor before taking supplements. Although all ingredients in VigRX are normal, Ginsing can interfere of other drugs – consult your doctor to make sure that there is no conflict. If you have medical conditions for which you take the drug (such as hypertension), or take sedatives or antidepressant, you will want certainly to check with your doctor before taking supplements of improvement of penis. Although these supplements are completely normal, the ingredients of sweet herbs are also strongly effective, and can affect other drugs. While it is the best to avoid Yohimbe strictly if you know have a cardiac disorder of kind, it is still possible to employ other supplements which do not contain Yohimbe, such as VigRX. VigRX has no Yohimbe that contains in it.
Always check the ingredients with your doctor before employing any new supplement. For example, VigRX contains the extract of sheet of Epimedium, used during more than 2000 years like sexual and reproductive tonic, and acts in the multiple ways to increase the capacity, the size, and the plenitude of construction. Epimedium contains a icariin called flavono. Icariin is an inhibitor PDE5 cGMP-specific just like one found in the drugs delivered on ordinance Viagra, Cialis and Levitra. A study at the university of Beijing in China (where Epimedium develops naturally) noted that this inhibitor can be developed in effective oral treatment for rectiles difficulties.
How happy seeing your penis size larger in length. The answer is to use natural male enhancement products. You should try the great male enhancement products as you have seen on TV.
Better Sex Than Viagra and Cialis
Filed under Cialis and Levitra, Impotence, Sildenafil Citrate by
Viagra, the popular drug that was accidentally discovered by a group of pharmaceutical chemists working at Pfizer's Sandwich, Kent, research facility in England, is a drug that seems to have a penchant for hogging the headlines since gaining approval as the first oral erectile dysfunction drug in 1998. If not in the news for its success in the treatment of men who are experiencing erectile dysfunction, it is in the news because of the rare side effects it produces in people who buy Viagra cheap online.
Only recently in 2007, a pilot scheme to sell Viagra over the counter was given a trial run by boots the chemist. Under the scheme, the drug would be made available to men between the ages of 30 and 65 who want to buy Viagra online without prescription.
The headline-grabbing ability continues with a report that suggested that buying Viagra tablets may help a man’s heart. According to the report, two studies conducted in San Francisco on the 19th of May showed that the erectile dysfunction drug may help a man’s heart, and men with high blood pressure stand the risk of becoming impotent.
Daniel T. Lackland, professor of epidemiology and medicine at the University of South Carolina in Charleston, was of the opinion that older and middle-aged men stood a higher risk of having erectile dysfunction, and the likelihood of not having their blood pressure under control was more in this same group of men.
Lackland added that the studies showed that it was important for men with erectile dysfunction to have their blood pressure checked and then controlled. The mere treatment of ED, the studies also showed, could improve aortic stiffness."
A report by Greek researchers at the American Society of Hypertension's 20th Annual Scientific Meeting and Exposition showed that Viagra reduces blood vessels stiffness – an indicator of atherosclerosis and a risk factor for heart disease – when used to treat impotent men who have high blood pressure.
According to statistics, about 65 million Americans have high blood pressure, a risk factor for kidney disease, stroke and heart disease. And it is believed that about 20 million men in America have some degree of erectile dysfunction.
The Connection between Blood Pressure and Erectile Dysfunction
Blood pressure and ED are not only connected, Greek researchers say, but for men who have high blood pressure, the risk of erectile dysfunction, when compared to men with normal blood pressure, is more than twice as high.
Michael Doumas, MD, from the fourth department of internal medicine at the University of Athens in Greece, in explaining the determination of their research, said that men with high blood pressure have a greater chance of being at risk for or having erectile dysfunction."
358 hypertensive men between the ages of 31 and 65 were involved in the study. According to the International Index of Erectile Function, the men were asked to complete a questionnaire that evaluated erectile dysfunction, after which they were compared with a group of men without high blood pressure by the researchers.
ED and Hypertension
Out of the thirty-five percent of men with high blood pressure with some degree of erectile dysfunction, about 9.2% of them were reported to have severe impotence.
Out of the men that have high blood pressure, 20% had erectile dysfunction and 89 had never used hypertension medications. Among these men:
• 160 were taking blood pressure drug and 36% suffered from erectile dysfunction.
• 107 were using two or more drugs to control their blood pressure, while 47% of these men suffered from ED.
In contrast, 14.1% of men that didn’t have high blood pressure had a certain degree of the condition, with 1.5% of these having severe impotence.
Filed under Prescription Viagra, Sildenafil Citrate by
Sildenafil Citrate is the active ingredient in the world’s most popular Erectile Dysfunction drug – Viagra. Originally developed as a means of treating pulmonary arterial hypertension, Sildenafil was discovered to be capable of producing firm erection in men. After further studying and testing the product, Sildenafil Citrate was approved by the Food and Drug Administration as the first oral treatment for erectile dysfunction in 1998. Though Boots the Chemist piloted a scheme to make the drug available to those who want to buy Viagra online with no prescription in 2007, Sildenafil is a prescription drug.
What is the impact of sildenafil citrate on the ED treatment market?
Viagra tablets, since hitting the market, have caused quite a sensation. Such is the success story of this drug in filling a gap in the ED market that other rival companies have formulated other drugs to boost the ranks of oral erectile dysfunction treatment. Notable among these rival drugs are Tadalafil – brand name Cialis – and Vardenafil – brand name Levitra. Also, some manufacturers are cashing in on the sildenafil brand using generic names to lure those who want to buy Viagra cheap prices to their sites.
Explaining the erectile effect of Sildenafil Citrate in medical terms.
Sildenafil citrate works by releasing nitric oxide in the corpus cavernosum of the penis. The nitric oxide binds to the receptors of the enzyme guanylate cyclase, after which the levels of cyclic guanosine monophosphate (cGMP) are raised with the subsequent relaxation of the muscles and increased blood flow and erection.
Explaining Sildenafil Citrate effects in Laymen terms
To the lay man, sildenafil works in the most natural and casual way in bringing about a stronger and longer penis erection.
For one to understand how Sildenafil works, one must first understand the process involved in penis erection. An easy way to grasp this is to mentally picture a balloon. A limp balloon has no air in it. Inflation of the limp balloon with just a little air makes it become swollen and rigid.
Erection of the penis is similar to the balloon. However, the penis uses pressurised blood instead of the pressurised air to become rigid. Present in the penis are two long tubes shaped like cigars. These cigar-like structures are known as the corpora cavernosa and they are what the penis uses to achieve erection. The arteries do their work by bringing blood into the two tubes, while the blood is taken away from the tubes by the veins.
The limpness or erection of the penis depends on the flow of blood into the corpus cavernosum.
For a flaccid penis, the arteries are somewhat constricted, while the veins are open. In this way no blood can build up in the penis, thus allowing for the penis to remain in its limp state. A sexually aroused man would experience the opening up of the arteries going to his penis to allow for the pressurised blood to flow into the penis. The veins going out of his penis constrict or close off and the pressurised blood becomes trapped in the cigar-like tubes and the penis elongates and stiffens subsequently. In this way, the penis has attained erection.
What physiological changes can cause erectile dysfunction?
For a sexually aroused man whose arteries – which take blood into the cigar-like tubes in the penis – fail to open up properly, the blood flow to the corpus cavernosum is restricted. Similarly, if the man veins carrying blood away from the corpus cavernosum fail to constrict, the blood flow out of the penis is rapid. In these two situations, erection would fail to occur.
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Viagra and generic Viagra in focus.
[mage source="flickr"]Viagra and generic Viagra in focus.[/mage]
Remain Fit With Regular Lovemaking
Are you sick and tired of going to the gym? Do you really want to lose weight without running on the treadmills, long walking, being on Atkins diet or taking diet pills like Acomplia? Here is an easy and highly recommended and proven solution for you! Have sex everyday and keep weight at bay or rather put it this way- sexercise is the best exercise.
Sexercise" is an unbeatable sway to stay slim and maintain weight. Combining sex and fitness is like killing two birds with one stone. Sex gets you fit. And being fit makes you want to have more sex. This is, in large part, because of all of the benefits a good sexercise routine offers, like: improved blood flow in strengthening your heart, better cholesterol, changing more of your bad cholesterol (LDL) to good cholesterol (HDL), weight control, better sleep and greater energy, including longer life and a better quality of life.
Not only has this, sexual fitness kept a women more attractive and rejuvenated, since they produce more estrogen. Sex provides shinier, smoother hair, glossy skin and a lot of energy. Both sexes glow as their skin pores become cleansed, thanks to sweating. They feel sexier than ever.
According to studies 30 minutes sex burns anywhere from 15-350 calories, depending on how physically active you are. This is the equivalent of calories burned during a half an hour of brisk walking, running, or lifting weights. Vigorous or longer sex sessions five times per week can burn up to 1,650 calories. The active partner who is on top is bound to get more benefit. Ladies should prefer the women on top position and make as many movements as they can.
Don't lose focus. You can easily get distracted with all of sex's delights. But your goal is to make it burn. In a matter of weeks, you can notice improvements in the tone and strength of your stomach, back, buttocks, legs and arms.
People who are missing the action due to minor disorders like erectile dysfunctions are advised to take Cialis or Viagra. Being away from sex can be an invitation to a lot of problems, leave aside he physical psychological and mental trauma.
Filed under Impotence, Sildenafil Citrate by
