Lesley Wilson said, ‘It will only be a routine prescription.’ Lesley Wilson was a female internal medicine physician attending to an eighty-year old retired airline executive, who had come to see Leslie in her office for a medical check-up, it seemed.
Realising that the opportunity to discuss his main reason for going to see Lesley in her office would soon be lost, the retired airline executive summoned up enough courage to ask Leslie about Viagra. Lesley, a female physician who was obviously used to the fact that most of her male patients found discussing such intimating issues as sex with her quite discomfiting, nodded her head in understanding.
Having just finished conducting a medical check-up on the retired executive, Lesley Wilson asked the man what was supposed to be a routine question for someone of that age group before making a prescription: Was he taking any heart treatment drug that is known to react with Viagra to fatally lower the blood pressure, like nitroglycerin?
After getting a negative answer from the man, Lesley had gone on to give the man a bottle containing six Viagra pills, what she had believed would be a routine prescription. However, the routine prescription turned out to be more complicated.
Lesley got the shocking news that the retired airline executive had died while having sex with his wife the previous day, two days later.
This story is a factual but rare incident of how people have lost their lives while having sex after taking Viagra tablets.
If reports from internet surveys are anything to be followed, the amount of sites now offering Viagra tablets for sale without prescription are on an alarming increase. If this trend is not bucked, however, not only would this people be at the risk of putting their health into their uninformed hands, they also have to contend with the inherent dangers from making transactions with internet sites whose authenticity or credibility is not well-known to them.
Viagra tablets, according to a report, have been associated with about thirty-one fatalities within the first year of the drug’s availability in the UK.
Although, these deaths could not be pinned directly to Viagra – apart from the knowledge that these people losing their lives within hours of taking Viagra tablets – the interaction of the drug with other drugs such as alpha blockers, have been said to be potentially harmful because the combination of the two drugs could lower the blood pressure to life-threatening levels.
The side effects of Viagra had been well documented before the launch of the drug, if the words of The Medicines Control Agency are to be quoted.
Any action that is deemed contrary to the warning conveyed in the label of Viagra for the drug not to be used in combination with nitrate drugs could result in a steep lowering of the blood pressure.
The number of fatalities would not have been unexpected given that a vast amount of patients who order Viagra tablets might have had underlying conditions predisposing to the erectile dysfunction which might have triggered cardiovascular events.
A marketing manager of Pfizer Inc. – which makes Viagra tablets – Andy Burrowes, refuted the growing claim that Viagra could be such a high risk medication. ‘This claim is highly unfounded,’ he was quoted.
‘It is mandated for doctors to report incidents of direct or indirect adverse effects of Viagra on patients. The death of these people, while after taking Viagra, does not mean Viagra could have been the definitive cause of their deaths.’ Burrowes added.
Could it be possible that these people lost their lives as a result of the complication from the underlying medical conditions causing their erectile problem?
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Generally known as the active ingredient in the world’s most popular erectile dysfunction drug – Viagra – Sildenafil citrate was originally developed by a group of pharmaceutical chemists working in Pfizer’s Kent Research facility as a cure for pulmonary arterial hypertension and angina pectoris. After surprisingly discovering that the drug could produce erection amongst men who were known to be suffering from erectile dysfunction, however, sildenafil citrate was patented and later approved by the Food and Drug Administration as the first oral treatment for erectile dysfunction in 1998.
Sildenafil citrate is predominantly sold as a prescription drug, though Boots the Chemist piloted a scheme to make the drug available to those who want to Buy Viagra with no prescription in 2007.
Examining the impact of Sildenafil Citrate on the ED treatment market.
Before the advent of Viagra tablets, the available treatment options for erectile dysfunction were largely unsatisfactory or inconvenient for use. Such drugs, like prostaglandin E1, which were injected topically into the penis, and insertion of prosthesis, which kept the penis perpetually erect were particularly unpopular because they were respectively not well known and convenient. The availability of Viagra tablets for sale, however, have brought about a massive positive change in the treatment of ED.
Not only do people order Viagra tablets because they are effective cure for the treatment of ED, people buy Viagra online with no prescription because the side effects and drug interactions of the pills are known.
The enormous success achieved by the drug, as clearly evinced by the high number of people who get Viagra tablets, have seen the introduction of a host of other ED drugs. Notable among the new drugs are: Tadalafil – brand name Cialis– and Vardenafil – brand name Levitra.
Medical explanation of the mechanism of action of Sildenafil Citrate.
As a potent inhibitor of phosphodiesterase type 5 enzyme (PDE 5), sildenafil citrate releases nitric oxide (NO) in the corpus cavernosum of the penis. The inhibition of the PDE 5 allows for the increased levels of the cyclic guanosine monophosphate (cGMP), and the NO binds to the receptors of the enzyme guanylate cyclase. The raised levels of cGMP allow for the relaxation of the smooth muscles and increased flow of blood to the penis and erection.
Laymen terms explanation of the mechanism of action of Sildenafil citrate
Sildenafil citrate, to the lay man, works naturally in bringing about a longer and stronger penile erection. To fully understand how Sildenafil Citrate works, it is pertinent to understand the process involved in penis erection. One simple way to getting round to this is to mentally picture a balloon. When a balloon is limp, it is generally assumed that there is no air in it. An inflation of the balloon, however, with just a little air makes it swell and rigid.
The erection of the penis works in an analogous manner to the inflation of a limp balloon. But unlike the balloon that uses pressurised air, the penis uses pressurised blood to achieve its erectile function.
The penis has two long cigar-like tubes known as the corpora cavernosa, and these tubes are what the penis uses to achieve erection. Normally, when a man is aroused, these tubes are filled with blood with the aid of the arteries, which carry blood to them. The arteries are normally constricted when a penis is flaccid, while the veins, which carry blood away from the penis, are open. This way, no blood is allowed to build up in the penis. But sexual arousal constricts the veins and dilates the arteries, thus allowing for the blood that flows into the corpus cavernosum to be trapped.
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